Most Who Meet Proposed CTE Criteria Do Not Show Disease Signs at Autopsy

Penn research finds proposed TES criteria often don’t match CTE pathology at autopsy, raising concerns about misdiagnosis and potential mental health impacts for at-risk groups. Most people who met proposed clinical criteria meant to identify chronic traumatic encephalopathy (CTE) during life did not show hallmark brain changes of the disease at autopsy. The findings raise concerns that widespread clinical adoption of these criteria could lead to misdiagnosis and unintended mental health conse